After beating the Crew in early April, the Impact will try to defeat Columbus yet again this coming weekend.
The Rapids, after losing both their starting goalkeeper and best defender to TFC, could have been facing a disastrous season. Instead, they find themselves near the top of the race for the Supporters' Shield.
Toronto FC are one of Montreal's fiercest rivals, but stopping them will be a tougher task than in years past.
The Fire, currently sitting in the East's final spot, could prove to be no pushover against the Impact, after some notable off-season acquisitions.
Having been eliminated by the Crew in last year's playoffs, the Impact will have to limit the Crew's ability to send crosses into their penalty area, as they proved difficult to cope with.
With the departure of Obafemi Martins, Seattle now relies heavily on the continued production of Clint Dempsey, along with the arrival of some new faces.
While FC Dallas can consistently rely on talent from their academy, the truly game-breaking plays come from their sneaky No. 10.